The mammalian central nervous system (CNS) produces behavior by integrating sensory inputs, memories and internal physiological states through a highly sophisticated network of cell-to-cell interactions. Members of our group seek to understand the development and function of neural systems that are essential to combat neurological disease and dysfunction.
Faculty in this research focus area examine basic structural and functional mechanisms underlying sensory processing, multisensory processing, memory formation, neural network rhythmicity and neuromodulation at molecular, cellular and network levels. The work we conduct has clinical implications for neurological disorders such as:
- Autism
- Epilepsy
- Alzheimer’s disease
- HIV-associated neurocognitive disorders
- Traumatic brain injury
Faculty
Kimberle M. Jacobs, PhD
Associate Professor
Kimberle M. Jacobs, PhD
Associate Professor
Department of Anatomy & Neurobiology
Phone: 804-827-2135
Pamela E. Knapp, Ph.D.
Professor and Chair
Pamela E. Knapp, Ph.D.
Professor and Chair
Department of Anatomy & Neurobiology
Phone: 804-628-7570
Email: pamela.knapp@vcuhealth.org
Gretchen N. Neigh (McCandless), Ph.D., MBA
Professor
Gretchen N. Neigh (McCandless), Ph.D., MBA
Professor
Department of Anatomy & Neurobiology
Phone: 804-628-5152
A. Rory McQuiston, Ph.D.
Professor
A. Rory McQuiston, Ph.D.
Professor
Department of Anatomy & Neurobiology
Phone: 804-828-1573
Email: adam.mcquiston@vcuhealth.org
M. Alex Meredith, Ph.D.
Professor Emeritus
M. Alex Meredith, Ph.D.
Professor Emeritus
Department of Anatomy & Neurobiology
John T. Povlishock, PhD
Professor, Retired
John T. Povlishock, PhD
Professor, Retired
Anatomy and Neurobiology
Phone: 804-828-9403
Ongoing Projects
Faculty: Kimberle Jacobs, Ph.D.
Sponsor: National Institute of Neurological Disorders and Stroke
Cost: $3,007,520
Duration: September 30, 2015 – July 31, 2020
Project Description: This project seeks to identify novel targets for treatment of epilepsy associated with developmental brain malformations. These studies will determine both cellular and systems mechanisms that contribute specifically to the onset of epileptiform activity, with the ultimate goal of developing preventative therapies or reparative treatments for children with intractable seizures.
Faculty: Kimberle Jacobs, Ph.D.
Sponsor: National Institute of Mental Health
Cost: $4,479,016
Duration: July 20, 2009 – June 30, 2024
Project Description: These studies seek to understand the molecular mechanism underlying the antidepressant action of hallucinogens to develop novel pharmacotherapies, which will mimic psilocybin’s antidepressant effect but lack its undesirable hallucinogenic properties.
Faculty: Adam “Rory” McQuiston, Ph.D.
Sponsor: National Institute of Mental Health
Cost: $1,906,250
Duration: April 11, 2016 – January 31, 2021
Project Description: This proposal seeks to identify mechanisms that control global brain states and activity that is essential for normal brain function.
Faculty: Adam “Rory” McQuiston, Ph.D.
Sponsor: National Institute on Aging
Cost: $426,250
Duration: July 15, 2017 – May 31, 2020
Project Description: These studies will help identify synaptic and neuronal sites impaired by pathogenic tau during early stages of Alzheimer's disease. It is hoped that discoveries from these studies will provide targets for future therapeutic investigations.
MPIs: Pamela Knapp, Ph.D and Kurt Hauser, Ph.D (Affiliate Faculty)
Faculty: Adam “Rory” McQuiston, Ph.D
Sponsor: National Institute on Drug Abuse
Cost: $1,209,747
Duration: April 1, 2018 – December 31, 2022
Project Description: The long-term goal of this project is to determine why specific neuronal subpopulations and associated neuronal networks are damaged by opiate abuse and HIV, and ultimately determine how deficits in striatal function might be rescued therapeutically.
MPIs: Pamela Knapp, Ph.D and Kurt Hauser, Ph.D (Affiliate Faculty)
Faculty: Adam “Rory” McQuiston, Ph.D
Sponsor: National Institute on Drug Abuse
Cost: $4,013,729
Duration: September 30, 2005 – December 31, 2021
Project Description: The long-term goal of this project is to identify how hippocampal interneurons and their associated glia are damaged by opiate abuse and HIV, and ultimately determine how structural and functional deficits in hippocampal neural circuitry might be rescued therapeutically.
Faculty: Marvin Meredith, Ph.D.
Sponsor: National Institute on Alcohol Abuse and Alcoholism
Cost: $6,240,051
Duration: May 15, 2017 – April 30, 2022
Project Description: This project seeks to explore the central hypothesis that alcohol exposure during development disrupts the functional and structural connectivity of multisensory cortical areas, thereby altering multisensory processing and contributing to neurobehavioral impairments in Fetal Alcohol Spectrum Disorders.